345 Weill Hall
Fenghua Hu is a research scientist in the Department of Molecular Biology and Genetics and is a member of the Weill Institute for Cell and Molecular Biology (Weill Institute). She received her B.S. in Biochemistry from Peking University in China in 1997 and her Ph.D. from Baylor College of Medicine in 2002. She received her postdoctoral training at Yale University, where she was awarded a Postdoctoral Fellowship from Paralyzed Veteran of American foundation.
My lab is interested in dissecting the disease mechanism of Frontal temporal lobe degeneration (FTLD) due to mutations in the progranulin gene. Progranulin encodes a secreted growth factor that regulates neuronal survival and inflammation. Progranulin haplo-insufficiency caused by progranulin mutations results in the accumulation of aggregates of a DNA and RNA binding protein called TDP-43. We are interested in studying pathways that control progranulin trafficking and progranulin signaling. Our goal is to understand how loss function of progranulin leads to accumulation of TDP-43 positive aggregates and neurodegeneration, and cellular machinery involved in clearing TDP-43 aggregates.
Neurons in the mammalian peripheral nervous system (PNS) can regrow functional axons after injury but neurons from adult mammalian central nervous system (CNS) cannot. The ability of neurons to regenerate is determined by both the surrounding environment and factors intrinsic to the damaged neuron. We are also interested identifying molecules and dissecting signaling pathways involved in axon outgrowth and regeneration.
Hu lab homepage