All of Dr. Lis' publications listed on PubMed.
For selected papers by technique, see our Research Interests pages.
Selected Reviews:
- Guertin MJ, Lis JT. (2012) "Mechanisms by which transcription factors gain access to target sequence elements in chromatin." Curr Opin Genet Dev 2012 Dec 19. doi:pii: S0959-437X(12)00138-4. 10.1016/j.gde.2012.11.008. [Epub ahead of print]. (PubMed)
- Adelman K, Lis JT. (2012) "Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans." Nat Rev Genet, 13(10):720-31. (PubMed)
- Petesch SJ, Lis JT. (2012) "Overcoming the nucleosome barrier during transcript elongation." Trends Genet, 28(6):285-94. (PubMed)
- Fuda NJ, Ardehali MB, Lis JT. (2009) "Defining mechanisms that regulate RNA polymerase II transcription in vivo." Nature, 461(7261):186-92. (PubMed)
- Lis, J. T. (2007) "Imaging Drosophila gene activation and polymerase pausing in vivo." Nature, 450(7167):198-202. (PubMed)
- Saunders, A., Core, L. J. and Lis, J. T. (2006) "Breaking Barriers to Transcription Elongation." Nature Reviews Molecular Cell Biology, 7: 557-567. (PubMed)
- Lis, J. (1998) "Promoter-Associated Pausing in Promoter Architecture and Post-Initiation Transcriptional Regulation." Cold Spring Harbor Symposium on Quantitative Biology. Volume LXIII. 347-56. (Article: PDF)
Selected Publications:
- Danko CG, Hah N, Luo X, Martins AL, Core L, Lis JT, Siepel A, Kraus WL. (2013) "Signaling Pathways Differentially Affect RNA Polymerase II Initiation, Pausing, and Elongation Rate in Cells." Mol Cell, 50(2):212-22. (PubMed)
- Kwak H, Fuda NJ, Core LJ, Lis JT. (2013) "Precise maps of RNA polymerase reveal how promoters direct initiation and pausing." Science, 339(6122):950-3. (PubMed)
- Core LJ, Waterfall JJ, Gilchrist DA, Fargo DC, Kwak H, Adelman K, Lis JT. (2012) "Defining the status of RNA polymerase at promoters." Cell Reports, 2(4):1025-35. (PubMed)
- Petesch SJ, Lis JT. (2012) "Activator-induced spread of poly(ADP-ribose) polymerase promotes nucleosome loss at Hsp70." Mol Cell, 45(1):64-74. (PubMed)
- Guertin MJ, Martins AL, Siepel A, Lis JT. (2012) "Accurate prediction of inducible transcription factor binding intensities in vivo." PLoS Genet, 8(3):e1002610. (PubMed)
- Min IM, Waterfall JJ, Core LJ, Munroe RJ, Schimenti J, Lis JT. (2011) "Regulating RNA polymerase pausing and transcription elongation in embryonic stem cells." Genes Dev, 25(7):742-54. (PubMed)
- Zobeck KL, Buckley MS, Zipfel WR, Lis JT. (2010) "Recruitment timing and dynamics of transcription factors at the Hsp70 loci in living cells." Mol Cell, 40(6):965-75. (PubMed)
- Guertin MJ, Lis JT. (2010) "Chromatin landscape dictates HSF binding to target DNA elements." PLoS Genet, 6(9). pii: e1001114. (PubMed)
- Ardehali MB, Lis JT. (2009) "Tracking rates of transcription and splicing in vivo." Nat Struct Mol Biol, 16(11):1123-4. (PubMed)
Here are some of our images that have been featured on the covers of the publishing journals. Click on the journal cover for the PubMed listing of the paper.
This page provides a series of resources which Lis Lab provides online, usually in conjunction with recent publications. Many of these resources are in PDF format and need to be downloaded and viewed using Adobe Acrobat Reader.
Full Text and Abstract (via ScienceMag.org) for Core, L.J. and Lis, J.T. (2008) "Transcription regulation through promoter-proximal pausing of RNA polymerase II." Science 319(5871):1791-2. (PubMed)
Supplemental data for Boehm et al. (2003) "Transcription factor and polymerase recruitment, modification, and movement on dhsp70 in vivo in the minutes following heat shock." Mol Cell Biol. 21:7628-37. (PubMed)
Full-size versions of the original images in Park et al. (2001) "Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock." Mol Cell. 8(1):9-19. (PubMed). This file allows for more clear viewing of the figures than allowed for in the printed publication.
Full-size versions of the original images in Andrulis et al. (2000) "High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation." Genes Dev. 14(20):2635-49. (PubMed) This file allows for more clear viewing of the figures than allowed for in the printed publication.
Full-size versions of the original images in Lis et al. (2000) "P-TEFb kinase recruitment and function at heat shock loci." Genes Dev. 14(7):792-803. (PubMed) This file allows for more clear viewing of the figures than allowed for in the printed publication.
Supplemental text and figures for Lee et al. (1999) "Different upstream transcriptional activators have distinct coactivator requirements." Genes Dev. 13(22):2934-9. (PubMed)
Directions on the construction of the lambda phage library described in Lin and Lis (1999) "Glycogen synthase phosphatase interacts with heat shock factor to activate CUP1 gene transcription in Saccharomyces cerevisiae." Mol Cell Biol. 19(5):3237-45. (PubMed)
Article: Lis, J. "Promoter-Associated Pausing in Promoter Architecture and Post-Initiation Transcriptional Regulation." Cold Spring Harbor Symposium on Quantitative Biology. Volume LXIII. 1998. 347-56.