The Nicholson Lab
Our research involves the application of multidimensional NMR spectroscopy to investigate the structure and dynamics of proteins in different functional states. We are focusing on key proteins that have been shown to play important roles in biological processes such as cell cycle control, cell signaling, protein degradation, organelle localization, protein folding and stability, bacterial infection/virulence, etc. Many of these proteins are implicated in disease processes such as Alzheimer's disease, diabetes, AIDS, and cancer.
Most NMR experiments run on a dedicated 600 MHz Varian spectrometer.
Research funded by grants from the National Science Foundation and the National Institute of Health.