Accessory Gland Proteins: ACPs
This project addresses the functions of male accessory gland proteins proteins (Acps, a component of the seminal fluid) that females receive from their mates. Our research provides insights into molecular and genetic mechanisms in reproduction, sex differences, hormone function, sperm storage, sperm competition and the rapid evolution of many reproductive proteins.
The changes in the egg that occur upon fertilization to allow it to transition to a developing embryo are collectively known as egg activation. Through pathways yet to be defined, increased calcium leads to completion of meiosis, changes in protein phosphorylation state, and other events characteristic of activation. We use Drosophila to investigate the signaling pathways for activation and the mediators of downstream events with a focus on the transition from meiosis to mitosis.