Andrew Grimson is an Associate Professor in the Department of Molecular Biology & Genetics. Dr. Grimson is a member of the Graduate Field of Biochemistry, Molecular and Cell Biology and the Graduate Field of Genetics, Genomics and Development. The Grimson lab focuses on post-transcriptional gene regulation, in particular the identity and function of animal microRNAs and other small RNAs.
My laboratory investigates post-transcriptional gene regulation. We have two areas of emphasis: first, the function of small RNA regulatory molecules (chiefly microRNAs), and second, the identification and characterization of novel cis-regulatory elements within mRNAs. These research areas represent my long-standing interest in the post-transcriptional regulation of mRNAs. As a graduate student, I investigated the NMD mRNA decay pathway, and as a postdoctoral fellow, I focused on miRNA target prediction and small RNA evolution. Our work typically combines high-throughput experimental and computational genomics, together with traditional experimental approaches. Ongoing projects include both fundamental studies in post-transcriptional regulation, for example: mechanistic characterization of novel regulatory pathways we have found; together with investigations into biological roles for post-transcriptional regulation, for example: investigating roles for small RNAs in the mammalian immune system.