Chun Han is a Nancy M. and Samuel C. Fleming Associate Professor in the Department of Molecular Biology and Genetics and the Weill Institute for Cell and Molecular Biology. He is a member of the Graduate Fields of Biochemistry, Molecular and Cell Biology (BMCB), Genetics, Genomics and Development (GG&D), and Neurobiology and Behavior (NB&B). After obtaining a B.S. degree in Cell Biology and Genetics in Peking University, China, he went to Cincinnati Children’s Hospital for his Ph.D, where he worked with Xinhua Lin to study morphogen gradient formation in Drosophila. He then joined the lab of Yuh Nung Jan at the University of California, San Francisco, as a Jane Coffin Childs postdoctoral fellow. He started his faculty position at Cornell in November, 2013.
Fundamental to its ability in forming neural circuits and processing information, each of the billions of neurons in the brain needs to establish and maintain a functional dendritic structure. The research in the Han lab is focused on deciphering the secret of dendrite development and dendrite degeneration. By using cutting edge technologies in molecular biology, cell biology, microscopy, and genetics, we wish to uncover core principles of dendrite morphogenesis at molecular and cellular levels both during normal development and in neuronal degeneration.
- Poe, A. R., Wang, B., Sapar, M. L., Ji, H., Li , K., Onabajo, T., Fazliyeva, R., Gibbs, M., Qiu, Y., Hu, Y., & Han, C. (2018). Robust CRISPR/Cas9-Mediated Tissue Specific Mutagenesis Reveals Gene Redundancy and Perdurance in <i>Drosophila</i>. Genetics.
- Sapar, M. L., Ji, H., Wang, B., Poe, A. R., Dubey, K., Ren, X., Ni, J. Q., & Han, C. (2018). Phosphatidylserine Externalization Results from and Causes Neurite Degeneration in Drosophila. Cell Reports. 24:2273-2286.
- Poe, A. R., Tang, L., Wang, B., Li, Y., Sapar, M. L., & Han, C. (2017). Dendritic space-filling requires a neuronal type-specific extracellular permissive signal in Drosophila. PNAS: Proceedings of the National Academy of Sciences of the United States of America. 114:E8062-E8071.
- Han, C. (2014). Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila. Neuron. 81:544-560.
- Han, C. (2012). Integrins regulate repulsion-mediated dendritic patterning of Drosophila sensory neurons by restricting dendrites in a 2D space. Neuron. 73:64-78.
- Han, C. (2011). Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila. PNAS: Proceedings of the National Academy of Sciences of the United States of America. 108:9673.