I obtained my Ph.D from Baylor College of Medicine and did my postdoctal training at Yale University. My lab is interested in studying the molecular mechanisms of Frontotemporal lobar degeneration.
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Awards and Honors
- New Investigator Award (2013) Alzheimer's Association
- Pilot grant (2012) AFTD
Selected Publications
Journal Publications
- Zhou, X., Sullivan, P. M., Sun, L., & Hu, F. (2017). The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C. JNC: Journal of Neurochemistry. 143:236-243.
- Zhou, X., Paushter, D. H., Feng, T., Sun, L., Reinheckel, T., & Hu, F. (2017). Lysosomal processing of progranulin. Molecular Neurodegeneration. 12:6.
- Zhou, X., Paushter, D. H., Feng, T., Pardon, C. M., Mendoza, C. S., & Hu, F. (2017). Regulation of cathepsin D activity by the FTLD protein progranulin. Acta Neuropathologica. 134:151-153.
- Zhou, X., Sun, L., Bracko, O., Choi, J. W., Jia, Y., Nana, A. L., Brady, O. A., Hernandez, Jean C. Cruz,, Nishimura, N., Seeley, W. W., & Hu, F. (2017). Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations. Nature Communications. 8:14.
- Zhou, X., Sun, L., Brady, O. A., Murphy, K. A., & Hu, F. (2017). Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency. Acta Neuropathologica Communications. 5:9.
- Sullivan, P. M., Zhou, X., Robins, A., Paushter, D., Kim, D., Smolka, M., & Hu, F. (2016). The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway. Acta Neuropathologica Communications. 4.
- Zhou, X., Sun, L., Oliveria, F., Qi, X., Brown, W. J., Smolka, M., Sun, Y., & Hu, F. (2015). Prosaposin facilitates sortilin independent lysosomal targeting of progranulin. JCB: The Journal of Cell Biology. 210:991.
- Brady, O. A., Zhou, X., & Hu, F. (2014). Regulated intramembrane proteolysis of the frontotemporal lobar degeneration (FTLD) risk factor,TMEM106B, by Signal Peptide Peptidase-like 2a (SPPL2a). JBC: Journal of Biological Chemistry. 289:19670.
- Brady, O. A., Zheng, Y., Murphy, K., Huang, M., & Hu, F. (2013). The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function. Human Molecular Genetics. 22:685-695.
- Zheng, Y., Brady, O., Meng, P., Mao, Y., & Hu, F. (2011). C-terminus of Progranulin interacts with the beta-propeller region of Sortilin to regulate Progranulin trafficking. PLOS One. 6:e21023.