Maureen R. Hanson is Liberty Hyde Bailey Professor in the Department of Molecular Biology & Genetics. She received a B.S. degree at Duke University and a Ph.D. in Cell and Developmental Biology from Harvard University. After completing an NIH postdoctoral fellowship at Harvard, she joined the faculty of the Biology Department at University of Virginia. She moved to Cornell as Associate Professor and was promoted to Professor in 1991. She is presently a member of the graduate Fields of Genetics and Development, Plant Biology, and Biochemistry, Molecular, and Cell Biology. She has previously served as Associate Director of the Cornell Biotechnology Program and Director of the Cornell Plant Science Center.
Dr. Hanson has two different research programs, related through their dependence on modern methods for examining genome sequences and gene expression. Her research in plant biology has always focused on the genome-containing organelles of plants, chloroplasts and mitochondria. Reflecting their prokaryotic origins, gene expression in these organelles differs from that of nuclear genes. In particular, organelle genes are often organized in operons that undergo considerable post-transcriptional processing, including RNA editing. The nuclear genome exerts significant control of organelle gene expression through the action of nuclear-encoded proteins targeted to the organelle. Research goals include identification of the components of the organelle RNA editing apparatus and an RNA/protein complex that suppresses the expression of an abnormal mitochondrial protein. Another study aims to identify proteins that control the morphology and movement of organelles. A third project concerns expression of bacterial microcompartments in chloroplasts in order to enhance the efficiency of photosynthesis. A second research area is the pathophysiology of the human illness Chronic Fatigue Syndrome, also known as Myalgic Encephalomyelitis. Individuals with this illness often have gastrointestinal issues and evidence of immune system activation and dysfunction. One current project involves characterization of the gut and blood microbiome in healthy vs. ill subjects. Another project aims to identify differences in gene expression at baseline and following exercise in healthy and in subjects diagnosed with CFS/ME.
Dr. Hanson teaches lab sessions on methods for producing transgenic organisms and on fluorescence microscopy. She participates in a lecture class concerning genetic engineering for basic research and practical application. She is the coordinator of a team-taught class on ethics in biological research.
- Germain, A., Ruppert, D., Levine, S. M., & Hanson, M. R. (2016). Metabolic profiling of a myalgic encephalomyelitis/ chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism. Molecular Biosystems.
- Billing-Ross, P., Germain, A., Ye, K., Keinan, A., Gu, Z., & Hanson, M. R. (2016). Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome. Journal of Translational Medicine. 14.
- Giloteaux, L., Goodrich, J. K., Walters, W. A., Levine, S. M., Ley, R., & Hanson, M. R. (2016). Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome. Microbiome. 4:30.
- Sun, T., Bentolila, S., & Hanson, M. R. (2016). The unexpected diversity of plant organelle RNA editosomes. Trends in Plant Science. 21:962-973.
- Hanson, M. R., Lin, M. T., Carmo-Silva, E., & Parry, M. A. (2016). Towards engineering carboxysomes into C3 plants. The Plant Journal. 87:38-50.
- Occhialini, A., Myat, L. T., Andralojc, P. J., Hanson, M. R., & Parry, M. A. (2016). Transgenic tobacco plants with improved cyanobacterial Rubisco expression but no extra assembly factors grow at near wild-type rates if provided with elevated CO2. The Plant Journal. 85:148-160.
- Sun, T., Shi, X., Friso, G., van Wijk, K., Bentolila, S., & Hanson, M. R. (2015). A zinc finger motif-containing protein is essential for chloroplast RNA editing. PLoS Genetics. 11:23 pages.
- Wagoner, J. A., Tao, S., Hanson, M. R., & Lin, L. (2015). Cytidine deaminase motifs within the DYW domain of two pentatricopeptide repeat-containing proteins are required for site-specific chloroplast RNA editing. Journal of Biological Chemistry. 290:2957-68.
- Shi, X., Hanson, M. R., & Bentolila, S. (2015). Two RNA recognition motif-containing proteins are plant mitochondrial editing factors. Nucleic Acids Research. 43:3814-3825..
- Lin, M. T., Occhialini, A., Andralojc, P. J., Parry, M. A., & Hanson, M. R. (2014). A faster Rubisco with potential to increase photosynthesis in crops. Nature. 513:547-50.
Presentations and Activities
- Mitochondrial Function and the Gut Microbiome in ME/CFS. Simmaron Research Update. August 2016. Simmaron Research Foundation. Incline Village, Nevada.
- Enhancing the Efficiency of Photosynthesis in C3 Plants. 5th Pan-American Conference on Plants and Bioenergy. August 2016. Santa Fe, New Mexico.
- Biomarkers from the Bacterial Microbiome in ME/CFS. InvestinME Conference. June 2016. InvestinME. London, England.
- Improving photosynthesis by chloroplast engineering. Seminar. April 2016. Michigan State University. East Lansing, MI.
- Post-transcriptional correction of plant organelle genome mutations by RNA editing. Seminar. April 2016. Western Michigan University. Kalamazoo, MI.
- Improving photosynthesis by chloroplast genome engineering. Seminar. March 2016. National University of Mexico. Cuernavaca, Mexico.
- RNA editing to rescue plants from organelle genome mutations. Plant and Animal Genome Meeting XXIV. January 2016. San Diego, CA.
- Enhancing Photosynthesis by Engineering Chloroplast Proteins. SIPS Symposium. September 2015. School of Integrative Plant Sciences. Ithaca, NY.
- Engineering Photosynthesis by Altering Chloroplast Proteins. Annual ASPB Meeting. July 2015. American Society of Plant Biologists. Minneapolis, MN.
- The Gut Microbiome in ME/CFS. Annual InvestinME Workshop. May 2015. InvestinME. London, England.