Skip to main content
Back to top
- A Role for Phospholipase A(2) Activity in Membrane Tubule Formation and TGN Trafficking.
Schmidt JA, Kalkofen DN, Donovan KW, Brown WJ.
Traffic. 2010 Sep 7. doi: 10.1111/j.1600-0854.2010.01115.x. [Epub ahead of print]
- Membrane topology of human AGPAT3 (LPAAT3).
Schmidt JA, Yvone GM, Brown WJ.
Biochem Biophys Res Commun. 2010 Jul 9;397(4):661-7.
- The phospholipase complex PAFAH Ib regulates the functional organization of the Golgi complex.
Bechler ME, Doody AM, Racoosin E, Lin L, Lee KH, Brown WJ.
J Cell Biol. 2010 Jul 12;190(1):45-53.
- Cytoplasmic phospholipase A2 antagonists inhibit multiple endocytic membrane trafficking pathways.
Doody AM, Antosh AL, Brown WJ.
Biochem Biophys Res Commun. 2009 Oct 30;388(4):695-9.
- Assembly of an intact Golgi complex requires phospholipase A2 (PLA2) activity, membrane tubules, and dynein-mediated microtubule transport.
Judson BL, Brown WJ.
Biochem Biophys Res Commun. 2009 Nov 20;389(3):473-7.
- Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function.
Schmidt JA, Brown WJ.
J Cell Biol. 2009 Jul 27;186(2):211-8.
- Assembly of an intact Golgi complex requires phospholipase A(2) (PLA(2)) activity, membrane tubules, and dynein-mediated microtubule transport.
Judson BL, Brown WJ.
Biochem Biophys Res Commun. 2009 Sep 9. [Epub ahead of print]
- A block in endoplasmic reticulum-to-Golgi trafficking inhibits phospholipid synthesis and induces neutral lipid accumulation.
Gaspar ML, Jesch SA, Viswanatha R, Antosh AL, Brown WJ, Kohlwein SD, Henry SA.
J Biol Chem. 2008 Sep 12;283(37):25735-51.
- The lysophospholipid acyltransferase antagonist CI-976 inhibits a late step in COPII vesicle budding.
Brown WJ, Plutner H, Drecktrah D, Judson BL, Balch WE.
Traffic. 2008 May;9(5):786-97
- Adipocyte differentiation-related protein reduces the lipid droplet association of adipose triglyceride lipase and slows triacylglycerol turnover.
Listenberger LL, Ostermeyer-Fay AG, Goldberg EB, Brown WJ, Brown DA.
J Lipid Res. 2007 Dec;48(12):2751-61.
- ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells.
Smirnova E, Goldberg EB, Makarova KS, Lin L, Brown WJ, Jackson CL.
EMBO Rep. 2006 Jan;7(1):106-13.
- A unique lysophospholipid acyltransferase (LPAT) antagonist, CI-976, affects secretory and endocytic membrane trafficking pathways.
Chambers K, Judson B, Brown WJ.
J Cell Sci. 2005 Jul 15;118(Pt 14):3061-71.
- Use of acyltransferase inhibitors to block vesicular traffic between the ER and Golgi complex.
Brown WJ, Schmidt JA.
Methods Enzymol. 2005;404:115-25.
- Inhibition of membrane tubule formation and trafficking by isotetrandrine, an antagonist of G-protein-regulated phospholipase A2 enzymes.
Chan D, Strang M, Judson B, Brown WJ.
Mol Biol Cell. 2004 Apr;15(4):1871-80.
- Characterization of a novel CI-976-sensitive lysophospholipid acyltransferase that is associated with the Golgi complex.
Chambers K, Brown WJ.
Biochem Biophys Res Commun. 2004 Jan 16;313(3):681-6.
- Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking.
Drecktrah D, Chambers K, Racoosin EL, Cluett EB, Gucwa A, Jackson B, Brown WJ.
Mol Biol Cell. 2003 Aug;14(8):3459-69.
- Phospholipase A2 (PLA2) enzymes in membrane trafficking: mediators of membrane shape and function.
Brown WJ, Chambers K, Doody A.
Traffic. 2003 Apr;4(4):214-21.
- Inhibition of transferrin recycling and endosome tubulation by phospholipase A2 antagonists.
de Figueiredo P, Doody A, Polizotto RS, Drecktrah D, Wood S, Banta M, Strang MS, Brown WJ.
J Biol Chem. 2001 Dec 14;276(50):47361-70.
- Phospholipase A2 antagonists inhibit constitutive retrograde membrane traffic to the endoplasmic reticulum.
de Figueiredo P, Drecktrah D, Polizotto RS, Cole NB, Lippincott-Schwartz J, Brown WJ.
Traffic. 2000 Jun;1(6):504-11.
- Clofibrate inhibits membrane trafficking to the Golgi complex and induces its retrograde movement to the endoplasmic reticulum.
de Figueiredo P, Brown WJ.
Cell Biol Toxicol. 1999;15(5):311-23.
- Phospholipase A(2) antagonists inhibit nocodazole-induced Golgi ministack formation: evidence of an ER intermediate and constitutive cycling.
Drecktrah D, Brown WJ.
Mol Biol Cell. 1999 Dec;10(12):4021-32.
- Stimulation of Golgi membrane tubulation and retrograde trafficking to the ER by phospholipase A(2) activating protein (PLAP) peptide.
Polizotto RS, de Figueiredo P, Brown WJ.
J Cell Biochem. 1999 Sep 15;74(4):670-83.
- Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists.
de Figueiredo P, Polizotto RS, Drecktrah D, Brown WJ.
Mol Biol Cell. 1999 Jun;10(6):1763-82.
- Evidence that phospholipase A2 activity is required for Golgi complex and trans Golgi network membrane tubulation.
de Figueiredo P, Drecktrah D, Katzenellenbogen JA, Strang M, Brown WJ.
Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8642-7.
- Retrograde trafficking of both Golgi complex and TGN markers to the ER induced by nordihydroguaiaretic acid and cyclofenil diphenol.
Drecktrah D, de Figueiredo P, Mason RM, Brown WJ.
J Cell Sci. 1998 Apr;111 ( Pt 7):951-65.
- Characterization of a cytosolic activity that induces the formation of Golgi membrane tubules in a cell-free reconstitution system.
Banta M, Polizotto RS, Wood SA, de Figueiredo P, Brown WJ.
Biochemistry. 1995 Oct 17;34(41):13359-66.
- Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.
Brown WJ, DeWald DB, Emr SD, Plutner H, Balch WE.
J Cell Biol. 1995 Aug;130(4):781-96.
- A role for calmodulin in organelle membrane tubulation.
de Figueiredo P, Brown WJ.
Mol Biol Cell. 1995 Jul;6(7):871-87.
- Biosynthesis and intracellular transport of a membrane glycoprotein (plgp57) of the prelysosome compartment.
Heller L, Park JE, Brown WJ.
Mol Membr Biol. 1994 Apr-Jun;11(2):127-34.
- Tubulation of Golgi membranes in vivo and in vitro in the absence of brefeldin A.
Cluett EB, Wood SA, Banta M, Brown WJ.
J Cell Biol. 1993 Jan;120(1):15-24.
- Inhibition of protein synthesis separates autophagic sequestration from the delivery of lysosomal enzymes.
Lawrence BP, Brown WJ.
J Cell Sci. 1993 Jun;105 ( Pt 2):473-80.
- Adhesion of Golgi cisternae by proteinaceous interactions: intercisternal bridges as putative adhesive structures.
Cluett EB, Brown WJ.
J Cell Sci. 1992 Nov;103 ( Pt 3):773-84.
- The morphology but not the function of endosomes and lysosomes is altered by brefeldin A.
Wood SA, Brown WJ.
J Cell Biol. 1992 Oct;119(2):273-85.
- Autophagic vacuoles rapidly fuse with pre-existing lysosomes in cultured hepatocytes.
Lawrence BP, Brown WJ.
J Cell Sci. 1992 Jul;102 ( Pt 3):515-26.
- Brefeldin A causes a microtubule-mediated fusion of the trans-Golgi network and early endosomes.
Wood SA, Park JE, Brown WJ.
Cell. 1991 Nov 1;67(3):591-600.
- Biosynthesis of lysosomal enzymes in cells of the End3 complementation group conditionally defective in endosomal acidification.
Park JE, Draper RK, Brown WJ.
Somat Cell Mol Genet. 1991 Mar;17(2):137-50.
- Identification of a membrane glycoprotein found primarily in the prelysosomal endosome compartment.
Park JE, Lopez JM, Cluett EB, Brown WJ.
J Cell Biol. 1991 Jan;112(2):245-55.
- Cation-independent mannose 6-phosphate receptors are concentrated in trans Golgi elements in normal human and I-cell disease fibroblasts.
Brown WJ.
Eur J Cell Biol. 1990 Apr;51(2):201-10.